Since anti-Ch and -Rg are considered to be clinically insignificant, is it important to investigate and identify them?

Even though anti-Ch and -Rg are clinically insignificant, they should be investigated and identified for the following reason:

  • Being directed against high frequency antigens, Chido and Rodgers antibodies can mask the presence of clinically significant antibodies.

Plasma inhibition can neutralize anti-Ch and -Rg, allowing co-existing antibodies to be identified. As well, enzyme-treated panels will prevent the reactivity of anti-Ch and -Rg but allow enzyme-enhanced antibodies (Rh and Kidd) to be identified.