Joom!Fish config error: Default language is inactive!
Please check configuration, try to use first active language

Case Study O1 - Discussion Part 4b - Answer (Question 1)

TraQ Program of the BC PBCO

Tuesday, 14 August 2018

Case Study O1 - Discussion Part 4b - Answer (Question 1)

What are anti-idiotype antibodies?

Anti-idiotype antibodies are directed against the binding sites of other antibodies that react with specific antigenic determinants (epitopes). Anti-idiotype antibodies may block immunological reactions as they resemble the epitope to which the first antibody reacts.

In this case study, anti-idiotype antibodies are mentioned as one of several possible hypotheses that may result in severe hemolysis when IV RhIG is used to treat ITP. Specifically, anti-idiotype antibodies in IV RhIG may form immune complexes that trigger the binding of complement and result in complement-mediated lysis of red cells.