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Case Study B5 - Case Discussion - Antibody kinetics in 1o and 2o immune responses
 

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Home Case Studies B-Level Case B5: Severe Delayed Hemolytic Transfusion Reaction Case Study B5 - Case Discussion - Antibody kinetics in 1o and 2o immune responses
Saturday, 24 June 2017

Case Study B5 - Case Discussion - Antibody kinetics in 1o and 2o immune responses

Antibody production differs in 1o and 2o immune responses. Pretransfusion testing attempts to prevent a 2° immune response by detecting any antibody present, and then ensuring that only antigen-negative red cells are transfused. The antibody screen cannot prevent a primary immune response because, unless autologous red cells or red cells from an identical twin are transfused, the recipient is exposed to foreign antigens.

Because pretransfusion testing in the transfusion service detects only 2o (anamnestic) immune responses, it is useful to review antibody kinetics in the two responses:

Discussion Question

  1. What can cause antibody levels to drop in a patient experiencing a delayed hemolytic transfusion reaction?

    Answer

Last modified on Friday, 28 October 2016 12:39