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Case Study A4 - Answer (Question 3)

TraQ Program of the BC PBCO

Saturday, 21 July 2018

Case Study A4 - Answer (Question 3)

What are the main symptoms of DHTR?

DHTR often go undetected because the reaction is subclinical or mild, and the patient may have been discharged from the hospital.

Red cells are typically destroyed slowly by extravascular hemolysis (EVH) in the liver (C3b-coated red cells) and spleen (IgG-sensitized red cells). If the extravascular system is overwhelmed, some red cells may be destroyed by intravascular hemolysis (IVH) if the antibodies involved bind complement that proceeds to C9 binding.

Common signs and symptoms include fever, chills, unexplained fall in hemoglobin, and mild jaundice.

Although extremely rare, DHTR can proceed to severe complications such as renal failure, and deaths have been reported.

Last modified on Wednesday, 22 December 2010 15:53